Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cellsArticle Published on 2022-11-022022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 진단, [키워드] Affect analyses autophagy Better boost cancer cell cancer cell lines Cell cell type ciliated conducted COVID-19 pathology COVID19 Critical eight endocytosed enterocytes experiment expressed Factor Genetic genetic screen Gut help Host host cell human cell human lung identify impair Infection Interaction lentiviruses loss-of-function lysosomal lysosomal membrane overexpression plac8 plasma Protein regulate respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses secretory cell single-cell SPNS1 spns1. susceptible viral entry viral infection virions [DOI] 10.15252/embj.2022110727 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
LRRC15 inhibits SARS-CoV-2 cellular entry in transArticle Published on 2022-10-132022-11-16 Journal: PLoS Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 Activation angiotensin-converting enzyme 2 bind block Cell cell type cellular entry coexpressed coronavirus 2 COVID-19 patients CRISPR dataset entry receptor expression Factor fibroblast human lung Infection inhibit inhibiting inhibitory LRRC15 lung moderate physiological protective role RBD regulate respiratory reveal SARS-CoV-2 SARS-CoV-2 entry Single-cell RNA sequencing Spike protein the receptor-binding domain viral entry [DOI] 10.1371/journal.pbio.3001805 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages macrophages. phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes. upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injuryArticle Published on 2022-09-092022-11-15 Journal: Genome Medicine [Category] 유전자 메커니즘, 진단, [키워드] Acute kidney injury adverse outcomes affected AKI Cell cell type changes in characterized Control COVID-19 criteria Critical Critical illness Critically ill patient diagnosed with COVID-19 disease disease-associated distal epithelial Gene Expression heterogeneity highlighting histology human kidney humans hypoxia Improving individual Injury inter-individual interferon response KDIGO kidney Kidney injury kidney tissue limbs mechanism molecular molecular responses occur oxidative stress performed Post-mortem provide proximal resource respiratory infections response reveal Sequencing single-cell sequencing. Single-cell transcriptomics subtype Therapies Transcriptome transcriptomic transcriptomics [DOI] 10.1186/s13073-022-01108-9 PMC 바로가기
Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19혈액-뇌장벽 기능 장애 및 SARS-CoV-2 감염에 대한 감수성에서 노화의 역할: COVID-19의 신경학적 증상에 대한 영향Review Published on 2022-08-182022-09-11 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] addition age aging alleviate astrocytes barrier blood-brain barrier Brain caused cell type Central nervous system cerebrospinal fluid CNS Comorbidity Corona Corona virus COVID-19 COVID-19 patients Cytokine storm deaths described diabete diabetes distress dysfunction endothelial cells endothelial function expression profile Hospitalization Impact inducer inflammatory reaction inflammatory reactions Interaction interactome microglia Mitochondria mitochondrial Mitochondrial function mitochondrial functions morbidity and mortality neurological Neurological symptom Neurological symptoms neurons Neurovascular outcome patients pericytes Pneumonia present respiratory respiratory distress risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus suggested susceptibility target therapy treat with COVID-19 [DOI] 10.1186/s12987-022-00357-5 PMC 바로가기 [Article Type] Review
Metacells untangle large and complex single-cell transcriptome networksMetacells는 크고 복잡한 단일 세포 전사체 네트워크를 풉니다.Article Published on 2022-08-132022-09-11 Journal: BMC Bioinformatics [Category] 유전자 메커니즘, [키워드] accelerate analysis build Cell cell type cell type annotation cells Clustering Coarse-graining complex Computational biology construction correlation COVID-19 patient COVID-19 patients demonstrated develop differential expression downstream analyses downstream analysis facilitate framework heterogeneous IMPROVE imputation inherent integration Interpretation less Metacells offer populations redundancy RNA RNA sequencing scRNA-seq scRNA-seq data significantly single-cell Single-cell RNA sequencing Single-cell transcriptomics Single-cell transcriptomics. SuperCell tissue Transcriptome transcriptomic unique Visualization [DOI] 10.1186/s12859-022-04861-1 PMC 바로가기 [Article Type] Article
Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents인간 폐 상피 조직 동등물에서 SARS-CoV-2 및 인플루엔자 감염 및 항바이러스 치료 모델링Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] alveolar Analysis antiviral drug Antiviral treatment antiviral treatments Biomarker cell type cell types cellular chemokine class Critical CXCL10 cytokine Cytokine storm develop emerging viruses epithelial exhibiting human lung IAV IFN response IL-10 IL-6 in vitro in vivo include infect Infection infections Influenza influenza A influenza A virus influenza infection MHC MHC class I modeling Pathogens peaking pharmacological platform Replication robust SARS-CoV-2 SARS-COV-2 infection severe SARS severe SARS-CoV-2 Single-cell RNA sequencing throughput tissue tissues tracheobronchial Validity Viral viral infection virus viruses [DOI] 10.1038/s42003-022-03753-7 PMC 바로가기 [Article Type] Article
Stem cell-based therapy for human diseases Reviews Published on 2022-08-062022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 임상, 치료제, [키워드] acute respiratory distress adipose Bone marrow Brain burns candidate cardiovascular conditions Cell cell type cellular phenotype clinical setting clinical trial contribute defined disease Diseases disorder disorders downstream human disease human diseases Hypothesis in vitro ISCT lineages mechanism MSC MSCs Neurological disorders Patient pluripotent stem cell progenitor cell provide pulmonary disease recent regenerative reproductive Research Society Spinal cord injury STEM stem cell Support syndrome targeted therapy therapy tissue translational treated Treatment UC-MSC umbilical [DOI] 10.1038/s41392-022-01134-4 [Article Type] Reviews